IHC-P analysis of mouse kidney tissue using GTX11148 Presenilin 2 antibody.
Presenilin 2 antibody
GTX11148
ApplicationsELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetPSEN2
Overview
- SupplierGeneTex
- Product NamePresenilin 2 antibody
- Delivery Days Customer9
- ApplicationsELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID5664
- Target namePSEN2
- Target descriptionpresenilin 2
- Target synonymsAD3L; AD3LP; AD4; AD5; Alzheimer disease 4; CMD1V; E5-1; presenilin-2; PS2; PS-2; STM2; STM-2
- HostGoat
- IsotypeIgG
- Scientific DescriptionAlzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203