PRMT5 antibody [PRMT5-21]
GTX12191
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityBovine, Canine, Chicken, Hamster, Human, Monkey, Mouse, Rat
Overview
- SupplierGeneTex
- Product NamePRMT5 antibody [PRMT5-21]
- Delivery Days Customer10
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDPRMT5-21
- Concentration~2 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionArginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins (Histone 2A, 3, 4), IL enhancer binding factor, nuclear factors (NF45, 90, ILF3, Nucleolin, STAT1, Poly(A) binding protein II), cell cycle proteins (phosphoprotein phosphatase 2A), signal transduction proteins (FGF2, Fibrillarin, FN, INFAR1, Jak, MBP, Src-adaptor Sam68), apoptosis proteins (FADD, ICE-like protease), and viral proteins (Hepatitis C NS3 RNA Helicase, HIV TAR). The mammalian PRMT family currently consists of 5 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all five PRMT members have been developed. These antibodies can be utilized to explore arginine methylation and its regulatory functions.
- ReactivityBovine, Canine, Chicken, Hamster, Human, Monkey, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203