Prostaglandin J2

MedChem Express

Prostaglandin J2 [60203-57-8]

10

60203-57-8

Research Use Only

14.95 mM

98.10

C20H30O4

334.45

Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with K i s of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC 50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimers (AD) and Parkinsons diseases (PD) [1] [2] [3] [4] .

CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C=CC1=O)C/C=C\CCCC(O)=O

-20°C

12352200