Prostaglandin J2 [60203-57-8]

TargetMol Chemicals

Prostaglandin J2 [60203-57-8]

44

60203-57-8

Chemical

Research Use Only

Prostaglandin J2

C20H30O4

334.45

Prostaglandin J2 (PGJ2), a derivative of Prostaglandin D2 (PGD2), serves as a potent agonist for PGD2 receptors (DP), exhibiting affinity constants (K i) of 0.9 nM and 6.6 nM for hDP and hCRTH2 receptors, respectively. It activates cyclic AMP production with an EC50 of 1.2 nM, induces oxidative stress, neuronal apoptosis, and promotes the accumulation of ubiquitinated (Ub) proteins. Notably, PGJ2s neurotoxic properties are implicated in the progression of neurodegenerative diseases such as Alzheimers (AD) and Parkinsons (PD) [1] [2] [3] [4].

3 years

CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)C=CC1=O

-20°C

12352200