PSEN2 Antibody

Aviva Systems Biology

PSEN2 Antibody

23

WB: 1:500 - 1:2,000. IHC: 1:50 - 1:200

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Liquid

PSEN2

presenilin 2

AD3L, AD4, CMD1V, PS2, STM2, presenilin-2, AD3LP, AD5, Alzheimer disease 3-like, Alzheimer disease 4, E5-1, PS-2, STM-2

Rabbit

IgG

Presenilin-2

Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Human, Mouse, Rat

-20°C

41116161