Western blot analysis of extracts of various cell lines using PSEN2 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using PSEN2 Polyclonal Antibody at 1:1000 dilution.
PSEN2 Polyclonal Antibody
E-AB-62184
Product group Antibodies
Overview
- SupplierElabscience
- Product NamePSEN2 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionAlzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
- UNSPSC12352203