PTCH1 antibody, Internal

GeneTex

PTCH1 antibody, Internal

9

This antibody is expected to recognise all four reported isoforms (NP_000255.2; NP_001077072.1; NP_001077071.1; NP_001077075.1).

WB: 1-3microg/ml. ICC/IF: 5microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

PTCH1

patched 1

BCNS; NBCCS; protein patched homolog 1; PTC; PTC1; PTCH

Goat

IgG

Protein patched homolog 1

This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017]

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203