More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/PTEN antibody

PTEN antibody

GTX101025
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
TargetPTEN
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    GeneTex
  • Product Name
    PTEN antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.68 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5728
  • Target name
    PTEN
  • Target description
    phosphatase and tensin homolog
  • Target synonyms
    10q23del; BZS; CWS1; DEC; GLM2; MHAM; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mutated in multiple advanced cancers 1; phosphatase and tensin-like protein; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase; PTEN variant PTEN-K267Rfs*9; PTEN variant PTEN-L247*; PTEN variant PTEN-R234Afs*11; PTEN1; PTENbeta; PTENepsilon; TEP1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP60484
  • Protein Name
    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  • Scientific Description
    This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • The Attenuation of Insulin/IGF-1 Signaling Pathway Plays a Crucial Role in the Myo-Inositol-Alleviated Aging in Caenorhabditis elegans.
    Read more
  • Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2.
    Read more
  • Sp1 transcription factor represses transcription of phosphatase and tensin homolog to aggravate lung injury in mice with type 2 diabetes mellitus-pulmonary tuberculosis. Zhao H et al., 2022 Apr, Bioengineered
    Read more
  • Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma. Liu S et al., 2021 Oct 19, Cell Rep Med
    Read more
  • E-cadherin Interacts With Posttranslationally-Modified AGO2 to Enhance miRISC Activity. Li JN et al., 2021, Front Cell Dev Biol
    Read more
  • The green tea polyphenol epigallocatechin-3-gallate attenuates age-associated muscle loss via regulation of miR-486-5p and myostatin. Chang YC et al., 2020 Oct 15, Arch Biochem Biophys
    Read more
  • Efficient Generation of Somatic Cell Nuclear Transfer-Competent Porcine Cells with Mutated Alleles at Multiple Target Loci by Using CRISPR/Cas9 Combined with Targeted Toxin-Based Selection System. Sato M et al., 2017 Dec 4, Int J Mol Sci
    Read more
  • Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway. Qian L et al., 2018 Feb, Cytotechnology
    Read more
  • miR-214 targets the PTEN-mediated PI3K/Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer. Liu J et al., 2017 Nov, Oncol Lett
    Read more
  • Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells. Chen NC et al., 2016 Feb 3, Sci Rep
    Read more

Related products

Product group Antibodies
References
Everest Biotech
Goat anti-PTENEB06544
ApplicationsImmunoPrecipitation, Western Blot, ELISA
TargetPTEN
  • SizePrice
Product group Antibodies
Assay Genie
PTEN AntibodyCAB2113
TargetPTEN
  • SizePrice
Product group Antibodies
Biomatik
Phosphatase And Tensin Homolog (PTEN) Polyclonal AntibodyCAU29991
ApplicationsImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
TargetPTEN
  • SizePrice
Paraformaldehyde-fixed, paraffin embedded Rat lung; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with PTEN Polyclonal Antibody, Unconjugated (bs-0686R) at 1:500 overnight at 4°C, DAB staining.
Product group Antibodies
References
Bioss Antibodies
PTEN Polyclonal AntibodyBS-0686R
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
TargetPTEN
  • SizePrice
Product group Antibodies
GeneTex
PTEN (phospho Ser380/Thr382/Thr383) antibodyGTX78959
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
TargetPTEN
  • SizePrice
Product group Antibodies
GeneTex
PTEN (phospho Ser380) antibodyGTX78960
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
TargetPTEN
  • SizePrice
FACS analysis of HeLa cells using GTX83304 PTEN antibody [1B8]. Right : PTEN Left : negative control
Product group Antibodies
References
GeneTex
PTEN antibody [1B8]GTX83304
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
TargetPTEN
  • SizePrice
WB (peptide competition) analysis of HEK293 cells transiently transfected with WT PTEN (Lane 1, 3-6) or mutant S385A (Lane 2) using GTX13590 PTEN (phospho Ser385) antibody prior incubated with the non-phosphopeptide corresponding to the immunogen (Lane 3), a generic phosphoserine-containing peptide (Lane 4), or the phosphopeptide immunogen (Lane 5). The data show that only the immunogen phosphopeptide blocks the signal, demonstrating the specificity of the antibody. The membrane treated with phosphatase (Lane 6) eliminates the signal further verifying that the antibody is phospho-specific.
Product group Antibodies
GeneTex
PTEN (phospho Ser385) antibodyGTX13590
ApplicationsWestern Blot
TargetPTEN
  • SizePrice
IHC-P analysis of human prostate carcinoma tissue using GTX17980 PTEN antibody [PTEN/2110].
Product group Antibodies
GeneTex
PTEN antibody [PTEN/2110]GTX17980
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
TargetPTEN
  • SizePrice
WB analysis of normal (control) and knockout (KO) HeLa cell lysate using GTX18153 PTEN antibody. Dilution : 1:1000 Loading : 25microg per lane
Product group Antibodies
GeneTex
PTEN antibodyGTX18153
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
TargetPTEN
  • SizePrice