ProductsBack/PUMA antibody [C2C3], C-term

PUMA antibody [C2C3], C-term

Name: PUMA antibody [C2C3], C-term
SKU: GTX109675_G10
Availability: BackOrder

GTX109675

ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetBBC3

Overview

Supplier
GeneTex
Product Name
PUMA antibody [C2C3], C-term
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID27113
Target name
BBC3
Target description
BCL2 binding component 3
Target synonyms
JFY-1, JFY1, PUMA, bcl-2-binding component 3, p53 up-regulated modulator of apoptosis, p53-upregulated modulator of apoptosis
Host
Rabbit
Isotype
IgG
Protein IDQ96PG8
Protein Name
Bcl-2-binding component 3, isoforms 3/4
Scientific Description
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Li J, Ding R, Gao H, et al. New spirobisnaphthalenes from an endolichenic fungus strain CGMCC 3.15192 and their anticancer effects through the P53-P21 pathway. RSC Adv. 2019,9(67):39082-39089. doi: 10.1039/c9ra07917c
Read this paper
Wei RJ, Lin SS, Wu WR, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016,311:88-98. doi: 10.1016/j.taap.2016.09.021
Read this paper
Chen MF, Huang SJ, Huang CC, et al. Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells. BMC Cancer. 2016,16:532. doi: 10.1186/s12885-016-2599-0
Read this paper
Chiu CF, Chang YW, Kuo KT, et al. NF-κB-driven suppression of FOXO3a contributes to EGFR mutation-independent gefitinib resistance. Proc Natl Acad Sci U S A. 2016,113(18):E2526-35. doi: 10.1073/pnas.1522612113
Read this paper
Wu DW, Lee MC, Hsu NY, et al. FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction. Oncogene. 2015,34(19):2505-15. doi: 10.1038/onc.2014.184
Read this paper