ProductsBack/PUMA antibody [C2C3], C-term

PUMA antibody [C2C3], C-term

Name: PUMA antibody [C2C3], C-term
SKU: GTX109675_G10
Availability: BackOrder

GTX109675

ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetBBC3

Overview

Supplier
GeneTex
Product Name
PUMA antibody [C2C3], C-term
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID27113
Target name
BBC3
Target description
BCL2 binding component 3
Target synonyms
bcl-2-binding component 3; JFY1; JFY-1; p53 up-regulated modulator of apoptosis; p53-upregulated modulator of apoptosis; PUMA
Host
Rabbit
Isotype
IgG
Protein IDQ96PG8
Protein Name
Bcl-2-binding component 3
Scientific Description
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

New spirobisnaphthalenes from an endolichenic fungus strain CGMCC 3.15192 and their anticancer effects through the P53-P21 pathway. Li J et al., 2019 Nov 27, RSC Adv
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A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Wei RJ et al., 2016 Nov 15, Toxicol Appl Pharmacol
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Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells. Chen MF et al., 2016 Jul 26, BMC Cancer
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NF-kappaB-driven suppression of FOXO3a contributes to EGFR mutation-independent gefitinib resistance. Chiu CF et al., 2016 May 3, Proc Natl Acad Sci U S A
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FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-kappaB/Slug-mediated PUMA reduction. Wu DW et al., 2015 May 7, Oncogene
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