Bio-Connect

Rad51 antibody [14B4]

GTX70230
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityChicken, Human, Mouse, Rat
TargetRAD51
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Overview

  • Supplier
    GeneTex
  • Product Name
    Rad51 antibody [14B4] - KO/KD, Orthogonal Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    14B4
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5888
  • Target name
    RAD51
  • Target description
    RAD51 recombinase
  • Target synonyms
    BRCA1/BRCA2-containing complex, subunit 5; BRCC5; DNA repair protein RAD51 homolog 1; FANCR; HRAD51; HsRad51; HsT16930; MRMV2; RAD51 homolog A; RAD51A; RECA; RecA, E. coli, homolog of; RecA-like protein; recombination protein A
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDQ06609
  • Protein Name
    DNA repair protein RAD51 homolog 1
  • Scientific Description
    The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
  • Reactivity
    Chicken, Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis.
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  • Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer.
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  • A carrier-free supramolecular nano-twin-drug for overcoming irinotecan-resistance and enhancing efficacy against colorectal cancer.
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  • Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma.
    Read more
  • Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells.
    Read more
  • INHAT subunit SET/TAF-Ibeta regulates PRC1-independent H2AK119 mono-ubiquitination via E3 ligase MIB1 in colon cancer.
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  • Performance of a RAD51-based functional HRD test on paraffin-embedded breast cancer tissue.
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  • Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers.
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  • Ex Vivo Functional Assay for Evaluating Treatment Response in Tumor Tissue of Head and Neck Squamous Cell Carcinoma.
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  • CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors.
    Read more