RANBP2 antibody [2E1] - Orthogonal Validated

GeneTex

RANBP2 antibody [2E1] - Orthogonal Validated

9

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

20

1 mg/ml

Unconjugated

RANBP2

RAN binding protein 2

358 kDa nucleoporin; acute necrotizing encephalopathy 1 (autosomal dominant); ADANE; ANE1; E3 SUMO-protein ligase RanBP2; E3 SUMO-protein transferase RanBP2; IIAE3; nuclear pore complex protein Nup358; nucleoporin 358; nucleoporin Nup358; NUP358; P270; ran-binding protein 2; transformation-related protein 2; TRP1; TRP2

Mouse

IgG2b

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]

Human

2°C to 8°C,-20°C or -80°C

12352203