Rb cleaved antibody [172C1094]

GeneTex

Rb cleaved antibody [172C1094]

9

The antibody recognizes cleaved Rb (DRb-p70). The antibody does not recognize full-length Rb.

WB: 2 microg/ml. IHC-Fr: 1:10 - 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

172C1094

0.5 mg/ml

Unconjugated

RB1

RB transcriptional corepressor 1

exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p105-Rb; p110-RB1; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; RB; retinoblastoma 1; retinoblastoma suspectibility protein; retinoblastoma-associated protein

Mouse

IgG1

Retinoblastoma-associated protein

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq]

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203