RNF40 Antibody

Cusabio

RNF40 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

RNF40

ring finger protein 40

BRE1B, RBP95, STARING, E3 ubiquitin-protein ligase BRE1B, 95 kDa retinoblastoma protein binding protein, 95 kDa retinoblastoma-associated protein, BRE1 E3 ubiquitin ligase homolog B, BRE1-B, RING-type E3 ubiquitin transferase BRE1B, Rb-associated protein, ring finger protein 40, E3 ubiquitin protein ligase

Rabbit

IgG

E3 ubiquitin-protein ligase BRE1B

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of Lys-120 of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.

Human

-20°C or -80°C

41116161