Ruxolitinib

MedChem Express

Ruxolitinib [941678-49-5]

10

941678-49-5

Research Use Only

99.99

C17H18N6

306.37

Ruxolitinib (INCB18424) is an orally active and selective JAK1/2 inhibitor with IC 50 s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3 [1] . Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy [3] .

N#CC[C@H](C1CCCC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2

-20°C,2°C to 8°C

12352200