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Chemical Structure
Chemical Structure
Chemical Structure

Ruxolitinib (free base) [941678-49-5]

Research Use Only
AG-CR1-3624
AdipoGen Life Sciences
CAS Number941678-49-5
Product group Chemicals
Estimated Purity>98%
Molecular Weight306.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Ruxolitinib (free base)
  • Delivery Days Customer
    10
  • CAS Number
    941678-49-5
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C17H18N6
  • Molecular Weight
    306.4
  • Scientific Description
    Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19). - Chemical. CAS: 941678-49-5. Formula: C17H18N6. MW: 306.4. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.
  • SMILES
    N#CC[C@H](C1CCCC1)N1C=C(C=N1)C1=NC=NC2=C1C=CN2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200