SAV1 Polyclonal Antibody

Reddot Biotech

SAV1 Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

1.32 mg/ml

Unconjugated

SAV1

salvador family WW domain containing protein 1

1700040G09Rik; 45 kDa WW domain protein; hWW45; protein salvador homolog 1; salvador homolog 1; SAV; WW domain-containing adaptor 45; WW45; WWP4

Rabbit

IgG

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

Human, Mouse, Rat

-20°C

12352203