SETD2 Polyclonal Antibody

Elabscience

SETD2 Polyclonal Antibody

12

ImmunoHistoChemistry

ELISA IHC

Research Use Only

Polyclonal

0.2 mg/ml

Unconjugated

SETD2

SET domain containing 2, histone lysine methyltransferase

HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, LLS, MRD70, RAPAS, SET2, p231HBP, histone-lysine N-methyltransferase SETD2, huntingtin interacting protein 1, huntingtin yeast partner B, huntingtin-interacting protein B, lysine N-methyltransferase 3A, protein-lysine N-methyltransferase SETD2

Rabbit

IgG

Histone-lysine N-methyltransferase SETD2

Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

-20°C

41116161