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ProductsBack/SHC1 (phospho Tyr239/Tyr240) antibody
IHC-P analysis of human colon carcinoma tissue using GTX24890 SHC1 (phospho Tyr239/Tyr240) antibody. Right : Primary antibody Left : Negative control without primary antibody Antigen retrieval : 10mM sodium citrate (pH 6.0), microwaved for 8-15 min Dilution : 1:20
IHC-P analysis of human colon carcinoma tissue using GTX24890 SHC1 (phospho Tyr239/Tyr240) antibody. Right : Primary antibody Left : Negative control without primary antibody Antigen retrieval : 10mM sodium citrate (pH 6.0), microwaved for 8-15 min Dilution : 1:20
IHC-P analysis of human colon carcinoma tissue using GTX24890 SHC1 (phospho Tyr239/Tyr240) antibody. Right : Primary antibody Left : Negative control without primary antibody Antigen retrieval : 10mM sodium citrate (pH 6.0), microwaved for 8-15 min Dilution : 1:20

SHC1 (phospho Tyr239/Tyr240) antibody

GTX24890
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSHC1
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Overview

  • Supplier
    GeneTex
  • Product Name
    SHC1 (phospho Tyr239/Tyr240) antibody - KO/KD, Orthogonal Validated
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody cross-reacts with over-expressed insulin receptor protein in CHO cells.
  • Application Supplier Note
    WB: 1:500. IHC-P: 1:10-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID6464
  • Target name
    SHC1
  • Target description
    SHC adaptor protein 1
  • Target synonyms
    SH2 domain protein C1; SHC; SHC (Src homology 2 domain containing) transforming protein 1; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP29353
  • Protein Name
    SHC-transforming protein 1
  • Scientific Description
    This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203