SHC1 (phospho Tyr239) antibody

GeneTex

SHC1 (phospho Tyr349) antibody

9

This antibody is raised against human SHC1 phosphorylated at Tyr349 of p66Shc (Uniprot #P29353-1). Based on sequence homology, it is corresponding to human SHC1 phosphorylated at Tyr239 of p52Shc (Uniprot #P29353-2).

WB: 1:500 - 1:1000. IHC-P: 1:100 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

SHC1

SHC adaptor protein 1

SH2 domain protein C1; SHC; SHC (Src homology 2 domain containing) transforming protein 1; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A

Rabbit

IgG

SHC-transforming protein 1

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Human

-20°C or -80°C,2°C to 8°C

12352203