SirReal1-O-propargyl

Biorbyt

SirReal1-O-propargyl

10

1862237-99-7

Research Use Only

98.00%

C21H20N4O2S2

424.54

SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent inhibitor of Sirtuin 2 (Sirt2), demonstrating an IC50 of 2.4 microM. It operates by binding to the cereblon ligand through a linker, facilitating the formation of PROTAC for the degradation of Sirt2[1].

O=C(NC1=NC=C(S1)CC=2C=CC=C(OCC#C)C2)CSC=3N=C(C=C(N3)C)C

-20°C

12352200