ProductsBack/SLD5 antibody [N1C3]

SLD5 antibody [N1C3]

Name: SLD5 antibody [N1C3]
SKU: GTX119779_G10
Availability: BackOrder

GTX119779

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetGINS4

Overview

Supplier
GeneTex
Product Name
SLD5 antibody [N1C3]
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID84296
Target name
GINS4
Target description
GINS complex subunit 4
Target synonyms
SLD5, DNA replication complex GINS protein SLD5, SLD5 homolog
Host
Rabbit
Isotype
IgG
Protein IDQ9BRT9
Protein Name
DNA replication complex GINS protein SLD5
Scientific Description
The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Liu B, Liu Z, Wang Y, et al. Overexpression of GINS4 is associated with poor prognosis and survival in glioma patients. Mol Med. 2021,27(1):117. doi: 10.1186/s10020-021-00378-0
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Shin G, Jeong D, Kim H, et al. RecQL4 tethering on the pre-replicative complex induces unscheduled origin activation and replication stress in human cells. J Biol Chem. 2019,294(44):16255-16265. doi: 10.1074/jbc.RA119.009996
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Yang R, Liu N, Chen L, et al. GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH. Oncogene. 2019,38(46):7133-7145. doi: 10.1038/s41388-019-0909-0
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Yang R, Liu N, Chen L, et al. LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer. J Exp Clin Cancer Res. 2019,38(1):280. doi: 10.1186/s13046-019-1276-y
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Jia W, Hsieh HY, Kidoya H, et al. Embryonic expression of GINS members in the development of the mammalian nervous system. Neurochem Int. 2019,129:104465. doi: 10.1016/j.neuint.2019.104465
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Li X, Qian X, Jiang H, et al. Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication. Mol Cell. 2018,72(4):650-660.e8. doi: 10.1016/j.molcel.2018.09.007
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