Smad1 (phospho Ser465) antibody

GeneTex

Smad1 (phospho Ser465) antibody

9

This antibody is raised against human Smad1 phosphorylated at Ser465. Based on sequence homology, it is predicted to react with smad5 and smad8(9) when phosphorylated at the corresponding residues - smad5 Ser465 and smad8(9) Ser467.

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

SMAD1

SMAD family member 1

BSP1; BSP-1; JV41; JV4-1; MAD, mothers against decapentaplegic homolog 1; MADH1; MADR1; Mad-related protein 1; mothers against decapentaplegic homolog 1; mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1

Rabbit

IgG

Phosphorylated

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Human

2°C to 8°C,-20°C or -80°C

12352203