Immunocytochemistry analysis of human liver cancer using CSB-PA022392EA01HU at dilution of 1:100
Immunocytochemistry analysis of human liver cancer using CSB-PA022392EA01HU at dilution of 1:100
SOCS3 Antibody
CSB-PA022392EA01HU
ApplicationsImmunoFluorescence, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetSOCS3
Overview
- SupplierCusabio
- Product NameSOCS3 Antibody
- Delivery Days Customer20
- ApplicationsImmunoFluorescence, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID9021
- Target nameSOCS3
- Target descriptionsuppressor of cytokine signaling 3
- Target synonymsATOD4; CIS3; Cish3; cytokine-inducible SH2 protein 3; SOCS-3; SSI3; SSI-3; STAT-induced STAT inhibitor 3; suppressor of cytokine signaling 3
- HostRabbit
- IsotypeIgG
- Protein IDO14543
- Protein NameSuppressor of cytokine signaling 3
- Scientific DescriptionSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203