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Sodium/Potassium ATPase beta 1 antibody

GTX113390
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetATP1B1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Sodium/Potassium ATPase beta 1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID481
  • Target name
    ATP1B1
  • Target description
    ATPase Na+/K+ transporting subunit beta 1
  • Target synonyms
    ATP1B, sodium/potassium-transporting ATPase subunit beta-1, ATPase, Na+/K+ transporting, beta 1 polypeptide, Beta 1-subunit of Na(+),K(+)-ATPase, Na, K-ATPase beta-1 polypeptide, adenosinetriphosphatase, sodium pump subunit beta-1, sodium-potassium ATPase subunit beta 1 (non-catalytic), sodium/potassium-dependent ATPase beta-1 subunit, sodium/potassium-transporting ATPase beta-1 chain
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP05026
  • Protein Name
    Sodium/potassium-transporting ATPase subunit beta-1
  • Scientific Description
    The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

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  • Wu SY, Wu HT, Wang YC, et al. Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo. Autophagy. 2023,19(4):1239-1257. doi: 10.1080/15548627.2022.2123098
    Read this paper
  • Williams D, Mehrabian M, Arshad H, et al. The cellular prion protein interacts with and promotes the activity of Na,K-ATPases. PLoS One. 2021,16(11):e0258682. doi: 10.1371/journal.pone.0258682
    Read this paper
  • Solarski M, Williams D, Mehrabian M, et al. The human brain somatostatin interactome: SST binds selectively to P-type family ATPases. PLoS One. 2019,14(5):e0217392. doi: 10.1371/journal.pone.0217392
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  • Tokhtaeva E, Sun H, Deiss-Yehiely N, et al. The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits. J Cell Sci. 2016,129(12):2394-406. doi: 10.1242/jcs.186148
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  • Flodby P, Kim YH, Beard LL, et al. Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance. Am J Respir Cell Mol Biol. 2016,55(3):395-406. doi: 10.1165/rcmb.2016-0005OC
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  • Kage H, Flodby P, Gao D, et al. Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury. Am J Physiol Lung Cell Mol Physiol. 2014,307(7):L524-36. doi: 10.1152/ajplung.00077.2014
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  • Ding WG, Xie Y, Toyoda F, et al. Improved functional expression of human cardiac kv1.5 channels and trafficking-defective mutants by low temperature treatment. PLoS One. 2014,9(3):e92923. doi: 10.1371/journal.pone.0092923
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  • Li G, Flodby P, Luo J, et al. Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014,51(2):210-22. doi: 10.1165/rcmb.2013-0353OC
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  • Wen X, Lacruz RS, Smith CE, et al. Gene-expression profile and localization of Na+/K(+)-ATPase in rat enamel organ cells. Eur J Oral Sci. 2014,122(1):21-6. doi: 10.1111/eos.12106
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