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SOX2 antibody [GT1876]

Name: SOX2 antibody [GT1876]
SKU: GTX627404_G10
Availability: BackOrder

GTX627404

ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse, Rat, Zebra Fish

TargetSOX2

Overview

Supplier
GeneTex
Product Name
SOX2 antibody [GT1876]
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:10000. IHC-Fr: 1:100-1:1000. FACS: 1:50-1:200. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
GT1876
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID6657
Target name
SOX2
Target description
SRY-box transcription factor 2
Target synonyms
ANOP3, MCOPS3, transcription factor SOX-2, SRY (sex determining region Y)-box 2, SRY-box 2, SRY-related HMG-box gene 2, sex determining region Y-box 2, transcription factor SOX2
Host
Mouse
Isotype
IgG1
Protein IDP48431
Protein Name
Transcription factor SOX-2
Scientific Description
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq]
Reactivity
Human, Mouse, Rat, Zebra Fish
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Mashiko T, Kanayama K, Saito N, et al. Selective Proliferation of Highly Functional Adipose-Derived Stem Cells in Microgravity Culture with Stirred Microspheres. Cells. 2021,10(3). doi: 10.3390/cells10030560
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Lee KY, Kuo TC, Chou CM, et al. Upregulation of CD109 Promotes the Epithelial-to-Mesenchymal Transition and Stemness Properties of Lung Adenocarcinomas via Activation of the Hippo-YAP Signaling. Cells. 2020,10(1). doi: 10.3390/cells10010028
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Zhang L, Liu F, Weygant N, et al. A novel integrated system using patient-derived glioma cerebral organoids and xenografts for disease modeling and drug screening. Cancer Lett. 2021,500:87-97. doi: 10.1016/j.canlet.2020.12.013
Read this paper
Ma L, Lou S, Miao Z, et al. Identification of novel susceptibility loci for non-syndromic cleft lip with or without cleft palate. J Cell Mol Med. 2020,24(23):13669-13678. doi: 10.1111/jcmm.15878
Read this paper
Andreucci E, Peppicelli S, Ruzzolini J, et al. The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells. J Mol Med (Berl). 2020,98(10):1431-1446. doi: 10.1007/s00109-020-01959-y
Read this paper
Aminuddin A, Ng PY, Leong CO, et al. Mitochondrial DNA alterations may influence the cisplatin responsiveness of oral squamous cell carcinoma. Sci Rep. 2020,10(1):7885. doi: 10.1038/s41598-020-64664-3
Read this paper
Peng L, Zhou Y, Xu W, et al. Generation of Stable Induced Pluripotent Stem-like Cells from Adult Zebra Fish Fibroblasts. Int J Biol Sci. 2019,15(11):2340-2349. doi: 10.7150/ijbs.34010
Read this paper
Lin YH, Wu MH, Huang YH, et al. Thyroid hormone negatively regulates tumorigenesis through suppression of BC200. Endocr Relat Cancer. 2018,25(12):967-979. doi: 10.1530/ERC-18-0176
Read this paper
Chuang HM, Ho LI, Huang MH, et al. Non-Canonical Regulation of Type I Collagen through Promoter Binding of SOX2 and Its Contribution to Ameliorating Pulmonary Fibrosis by Butylidenephthalide. Int J Mol Sci. 2018,19(10). doi: 10.3390/ijms19103024
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Chang KY, Huang CT, Hsu TI, et al. Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma. Biochem Biophys Res Commun. 2017,493(1):14-19. doi: 10.1016/j.bbrc.2017.09.095
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SOX2 antibody [GT1876]

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