SOX2 antibody [GT1352]
GTX627405
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetSOX2
Overview
- SupplierGeneTex
- Product NameSOX2 antibody [GT1352]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IHC-Fr: 1:100-1:1000. FACS: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDGT1352
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID6657
- Target nameSOX2
- Target descriptionSRY-box transcription factor 2
- Target synonymsANOP3, MCOPS3, transcription factor SOX-2, SRY (sex determining region Y)-box 2, SRY-box 2, SRY-related HMG-box gene 2, sex determining region Y-box 2, transcription factor SOX2
- HostMouse
- IsotypeIgG2a
- Protein IDP48431
- Protein NameTranscription factor SOX-2
- Scientific DescriptionThis intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Kitagawa T, Kobayashi D, Baron B, et al. AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing's sarcoma cells. PLoS One. 2022,17(10):e0269077. doi: 10.1371/journal.pone.0269077Read this paper
- Kim SH, Fan PW, Hsieh CH, et al. The aqueous extract of brucea javanica reduces tumorigenicity of human lung cancer tumorspheres. Cancer Drug Resist. 2021,4(4):866-880. doi: 10.20517/cdr.2021.58Read this paper
- Skałbania J, Pałasz A, Błaszczyk I, et al. Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone. Pharmacol Rep. 2021,73(4):1164-1169. doi: 10.1007/s43440-021-00259-7Read this paper
- Ramírez-Rentería C, Espinosa-De-Los-Monteros AL, Etual EC, et al. From ACTH-Dependent to ACTH-Independent Cushing's Syndrome from a Malignant Mixed Corticomedullary Adrenal Tumor: Potential Role of Embryonic Stem Cells. Case Rep Endocrinol. 2020,2020:4768281. doi: 10.1155/2020/4768281Read this paper
- Ooizumi Y, Kojima K, Igarashi K, et al. Comprehensive Exploration to Identify Predictive DNA Markers of ΔNp63/SOX2 in Drug Resistance in Human Esophageal Squamous Cell Carcinoma. Ann Surg Oncol. 2019,26(13):4814-4825. doi: 10.1245/s10434-019-07795-wRead this paper
- Yang SC, Liu JJ, Wang CK, et al. Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2. FASEB J. 2019,33(9):10577-10592. doi: 10.1096/fj.201800220RRRead this paper
Datasheet
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