SP600125

BPS Bioscience

SP600125

7

129-56-6

Research Use Only

≥99%

C14H8N2O

220.2 Da

Novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki = 0.19 microM). SP600125 is an ATP-competitive reversible inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-alpha, IFN-gamma, and blocked the activation and differentiation of primary human CD4 cell cultures.

-20°C

12352200