Bio-Connect

SPOP antibody [N1C1]

GTX106942
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetSPOP
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Overview

  • Supplier
    GeneTex
  • Product Name
    SPOP antibody [N1C1]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID8405
  • Target name
    SPOP
  • Target description
    speckle type BTB/POZ protein
  • Target synonyms
    BTBD32; HIB homolog 1; NEDMACE; NEDMIDF; NSDVS1; NSDVS2; roadkill homolog 1; speckle-type POZ protein; TEF2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO43791
  • Protein Name
    Speckle-type POZ protein
  • Scientific Description
    This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis. He Y et al., 2021 Nov 27, Cancer Cell Int
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  • SPOP promotes FADD degradation and inhibits NF-kappaB activity in non-small cell lung cancer. Luo J et al., 2018 Sep 26, Biochem Biophys Res Commun
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  • SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth. Luo J et al., 2017 Feb 5, Biochem Biophys Res Commun
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  • Mutational and expressional analyses of SPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers. Kim MS et al., 2013 Jul, APMIS
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