ProductsBack/SPOP antibody [N1C1]

SPOP antibody [N1C1]

Name: SPOP antibody [N1C1]
SKU: GTX106942_G10
Availability: BackOrder

GTX106942

ApplicationsWestern Blot, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman, Mouse

TargetSPOP

Overview

Supplier
GeneTex
Product Name
SPOP antibody [N1C1]
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.1 mg/ml
Conjugate
Unconjugated
Gene ID8405
Target name
SPOP
Target description
speckle type BTB/POZ protein
Target synonyms
BTBD32, NEDMACE, NEDMIDF, NSDVS1, NSDVS2, TEF2, speckle-type POZ protein, HIB homolog 1, roadkill homolog 1
Host
Rabbit
Isotype
IgG
Protein IDO43791
Protein Name
Speckle-type POZ protein
Scientific Description
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq]
Reactivity
Human, Mouse
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

He Y, Chen J, Peng X, et al. Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis. Cancer Cell Int. 2021,21(1):626. doi: 10.1186/s12935-021-02329-5
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Luo J, Chen B, Gao CX, et al. SPOP promotes FADD degradation and inhibits NF-κB activity in non-small cell lung cancer. Biochem Biophys Res Commun. 2018,504(1):289-294. doi: 10.1016/j.bbrc.2018.08.176
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Luo J, Bao YC, Ji XX, et al. SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth. Biochem Biophys Res Commun. 2017,483(2):880-884. doi: 10.1016/j.bbrc.2017.01.027
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Kim MS, Je EM, Oh JE, et al. Mutational and expressional analyses of SPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers. APMIS. 2013,121(7):626-33. doi: 10.1111/apm.12030
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