SREBP1 (phospho Ser439) antibody

GeneTex

SREBP1 (phospho Ser439) antibody

9

WB: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

SREBF1

sterol regulatory element binding transcription factor 1

bHLHd1; class D basic helix-loop-helix protein 1; HMD; IFAP2; SREBP1; sterol regulatory element-binding protein 1

Rabbit

IgG

Sterol regulatory element-binding protein 1

This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]

Human

-20°C or -80°C,2°C to 8°C

12352203