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STAT5B(STAT5B/2611), CF405S conjugate, 0.1mg/mL [26628-22-8]

STAT5B(STAT5B/2611), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC042611
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetSTAT5B
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Overview

  • Supplier
    Biotium
  • Product Name
    STAT5B(STAT5B/2611), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    STAT5B/2611
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID6777
  • Target name
    STAT5B
  • Target description
    signal transducer and activator of transcription 5B
  • Target synonyms
    GHISID2; signal transducer and activator of transcription 5B; STAT5; transcription factor STAT5B
  • Host
    Mouse
  • Isotype
    IgG
  • Protein IDP51692
  • Protein Name
    Signal transducer and activator of transcription 5B
  • Scientific Description
    Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203