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SUCLA2 antibody [N2C3]

Research Use Only
GTX109728
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetSUCLA2
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Overview

  • Supplier
    GeneTex
  • Product Name
    SUCLA2 antibody [N2C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID8803
  • Target name
    SUCLA2
  • Target description
    succinate-CoA ligase ADP-forming subunit beta
  • Target synonyms
    A-BETA; A-SCS; ATP-specific succinyl-CoA synthetase subunit beta; ATP-specific succinyl-CoA synthetase, beta subunit; LINC00444; long intergenic non-protein coding RNA 444; mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta; MTDPS5; renal carcinoma antigen NY-REN-39; SCS-betaA; succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; succinate-CoA ligase ADP-forming beta subunit; succinate-CoA ligase beta subunit; succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial; succinyl-CoA synthetase beta-A chain
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9P2R7
  • Protein Name
    Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
  • Scientific Description
    Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Loss of succinyl-CoA synthase ADP-forming beta subunit disrupts mtDNA stability and mitochondrial dynamics in neurons. Zhao Y et al., 2017 Aug 2, Sci Rep
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  • A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase. Piel RB 3rd et al., 2016 Sep 20, Biochemistry
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  • Identification of the Mitochondrial Heme Metabolism Complex. Medlock AE et al., 2015, PLoS One
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