SUCLA2 antibody [N2C3]
GTX109728
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetSUCLA2
Overview
- SupplierGeneTex
- Product NameSUCLA2 antibody [N2C3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID8803
- Target nameSUCLA2
- Target descriptionsuccinate-CoA ligase ADP-forming subunit beta
- Target synonymsA-BETA, A-SCS, LINC00444, MTDPS5, SCS-betaA, succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial, ATP-specific succinyl-CoA synthetase subunit beta, ATP-specific succinyl-CoA synthetase, beta subunit, long intergenic non-protein coding RNA 444, mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta, renal carcinoma antigen NY-REN-39, succinate-CoA ligase ADP-forming beta subunit, succinate-CoA ligase beta subunit, succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial, succinyl-CoA synthetase beta-A chain
- HostRabbit
- IsotypeIgG
- Protein IDQ9P2R7
- Protein NameSuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
- Scientific DescriptionSuccinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Zhao Y, Tian J, Sui S, et al. Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons. Sci Rep. 2017,7(1):7169. doi: 10.1038/s41598-017-05168-5Read this paper
- Piel RB 3rd, Shiferaw MT, Vashisht AA, et al. A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase. Biochemistry. 2016,55(37):5204-17. doi: 10.1021/acs.biochem.6b00756Read this paper
- Medlock AE, Shiferaw MT, Marcero JR, et al. Identification of the Mitochondrial Heme Metabolism Complex. PLoS One. 2015,10(8):e0135896. doi: 10.1371/journal.pone.0135896Read this paper





