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Syk antibody [N2C2], Internal

GTX100748
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetSYK
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Overview

  • Supplier
    GeneTex
  • Product Name
    Syk antibody [N2C2], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.32 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID6850
  • Target name
    SYK
  • Target description
    spleen associated tyrosine kinase
  • Target synonyms
    IMD82; p72-Syk; spleen tyrosine kinase; tyrosine-protein kinase SYK
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP43405
  • Protein Name
    Tyrosine-protein kinase SYK
  • Scientific Description
    This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis.
    Read more
  • Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis. Jia Y et al., 2019 Jan 15, Cell Death Dis
    Read more
  • Tetrandrine attenuates the bone erosion in collagen-induced arthritis rats by inhibiting osteoclastogenesis via spleen tyrosine kinase. Jia Y et al., 2018 Jun, FASEB J
    Read more
  • SH3BP2 cherubism mutation potentiates TNF-alpha-induced osteoclastogenesis via NFATc1 and TNF-alpha-mediated inflammatory bone loss. Mukai T et al., 2014 Dec, J Bone Miner Res
    Read more

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