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ProductsBack/Syk antibody [N2C2], Internal
SYK antibody [N2C2], Internal detects SYK protein by western blot analysis. A. 30 μg mouse BMDM (bone marrow-derived macrophage) cells B. 30 μg mouse Syk null cells 10% SDS-PAGE SYK antibody [N2C2], Internal (GTX100748) dilution: 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
SYK antibody [N2C2], Internal detects SYK protein by western blot analysis. A. 30 μg mouse BMDM (bone marrow-derived macrophage) cells B. 30 μg mouse Syk null cells 10% SDS-PAGE SYK antibody [N2C2], Internal (GTX100748) dilution: 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
SYK antibody [N2C2], Internal detects SYK protein by western blot analysis. A. 30 μg mouse BMDM (bone marrow-derived macrophage) cells B. 30 μg mouse Syk null cells 10% SDS-PAGE SYK antibody [N2C2], Internal (GTX100748) dilution: 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Syk antibody [N2C2], Internal

GTX100748
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSYK
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Overview

  • Supplier
    GeneTex
  • Product Name
    Syk antibody [N2C2], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.32 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID6850
  • Target name
    SYK
  • Target description
    spleen associated tyrosine kinase
  • Target synonyms
    IMD82, p72-Syk, tyrosine-protein kinase SYK, spleen tyrosine kinase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP43405
  • Protein Name
    Tyrosine-protein kinase SYK
  • Scientific Description
    This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Tsukui D, Kimura Y, Kono H. GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis. iScience. 2023,26(8):107293. doi: 10.1016/j.isci.2023.107293
    Read this paper
  • Jia Y, Tao Y, Lv C, et al. Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis. Cell Death Dis. 2019,10(2):38. doi: 10.1038/s41419-018-1286-2
    Read this paper
  • Jia Y, Miao Y, Yue M, et al. Tetrandrine attenuates the bone erosion in collagen-induced arthritis rats by inhibiting osteoclastogenesis via spleen tyrosine kinase. FASEB J. 2018,32(6):3398-3410. doi: 10.1096/fj.201701148RR
    Read this paper
  • Mukai T, Ishida S, Ishikawa R, et al. SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss. J Bone Miner Res. 2014,29(12):2618-35. doi: 10.1002/jbmr.2295
    Read this paper

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