ProductsBack/Syk antibody [N2C2], Internal

Syk antibody [N2C2], Internal

Name: Syk antibody [N2C2], Internal
SKU: GTX100748_G10
Availability: BackOrder

GTX100748

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetSYK

Overview

Supplier
GeneTex
Product Name
Syk antibody [N2C2], Internal
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.32 mg/ml
Conjugate
Unconjugated
Gene ID6850
Target name
SYK
Target description
spleen associated tyrosine kinase
Target synonyms
IMD82; p72-Syk; spleen tyrosine kinase; tyrosine-protein kinase SYK
Host
Rabbit
Isotype
IgG
Protein IDP43405
Protein Name
Tyrosine-protein kinase SYK
Scientific Description
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis.
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Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis. Jia Y et al., 2019 Jan 15, Cell Death Dis
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Tetrandrine attenuates the bone erosion in collagen-induced arthritis rats by inhibiting osteoclastogenesis via spleen tyrosine kinase. Jia Y et al., 2018 Jun, FASEB J
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SH3BP2 cherubism mutation potentiates TNF-alpha-induced osteoclastogenesis via NFATc1 and TNF-alpha-mediated inflammatory bone loss. Mukai T et al., 2014 Dec, J Bone Miner Res
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