Overview
- SupplierGeneTex
- Product NameTAK1 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.2 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. Wu HH et al., 2015 Mar 9, J Exp MedRead more