Tal1(TAL1/3146), CF594 conjugate, 0.1mg/mL [26628-22-8]

Biotium

Tal1(TAL1/3146), CF594 conjugate, 0.1mg/mL

9

Research Use Only

Monoclonal

TAL1/3146

0.1 mg/ml

Other Conjugate

TAL1

TAL bHLH transcription factor 1, erythroid differentiation factor

bHLHa17; class A basic helix-loop-helix protein 17; SCL; stem cell protein; tal-1; tal-1 product; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; TCL5

Mouse

IgG1

T-cell acute lymphocytic leukemia protein 1

Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase II, a serine/threonine protein kinase known to modulate the activity of other HLH transcription factors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Human

2°C to 8°C

12352203