TCL1A antibody [TCL1/2078]

GeneTex

TCL1A antibody [TCL1/2078]

9

IHC-P: 1-2microg/ml for 30 minutes at RT. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application

Research Use Only

Monoclonal

TCL1/2078

0.2 mg/ml

Unconjugated

Liquid

TCL1A

TCL1 family AKT coactivator A

oncogene TCL1; oncogene TCL-1; protein p14 TCL1; T cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma protein 1A; T-cell lymphoma-1; TCL1

Mouse

IgG1

T-cell leukemia/lymphoma protein 1A

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

Human

-20°C or -80°C,2°C to 8°C

12352203