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TDG antibody

Name: TDG antibody
SKU: GTX110473_G10
Availability: BackOrder

GTX110473

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

TargetTDG

Overview

Supplier
GeneTex
Product Name
TDG antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID6996
Target name
TDG
Target description
thymine DNA glycosylase
Target synonyms
G/T mismatch-specific thymine DNA glycosylase; hTDG
Host
Rabbit
Isotype
IgG
Protein IDQ13569
Protein Name
G/T mismatch-specific thymine DNA glycosylase
Scientific Description
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1. Liu X et al., 2021 Jul 15, Mol Cell
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Caspase-8, receptor-interacting protein kinase 1 (RIPK1), and RIPK3 regulate retinoic acid-induced cell differentiation and necroptosis. Someda M et al., 2020 May, Cell Death Differ
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Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo. McLaughlin D et al., 2016 Apr 22, J Biol Chem
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Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells. Jin C et al., 2015, Epigenetics
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SUMO-modification and elimination of the active DNA demethylation enzyme TDG in cultured human cells. Moriyama T et al., 2014 May 9, Biochem Biophys Res Commun
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Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer. Xu X et al., 2014 Mar 28, J Biol Chem
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