TDG antibody
GTX110473
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetTDG
Overview
- SupplierGeneTex
- Product NameTDG antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID6996
- Target nameTDG
- Target descriptionthymine DNA glycosylase
- Target synonymsG/T mismatch-specific thymine DNA glycosylase; hTDG
- HostRabbit
- IsotypeIgG
- Protein IDQ13569
- Protein NameG/T mismatch-specific thymine DNA glycosylase
- Scientific DescriptionThe protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1. Liu X et al., 2021 Jul 15, Mol CellRead more
- Caspase-8, receptor-interacting protein kinase 1 (RIPK1), and RIPK3 regulate retinoic acid-induced cell differentiation and necroptosis. Someda M et al., 2020 May, Cell Death DifferRead more
- Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo. McLaughlin D et al., 2016 Apr 22, J Biol ChemRead more
- Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells. Jin C et al., 2015, EpigeneticsRead more
- SUMO-modification and elimination of the active DNA demethylation enzyme TDG in cultured human cells. Moriyama T et al., 2014 May 9, Biochem Biophys Res CommunRead more
- Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer. Xu X et al., 2014 Mar 28, J Biol ChemRead more