Immunofluorescent analysis of A549 cells, using TARDBP antibody GTX30809 at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Immunofluorescent analysis of A549 cells, using TARDBP antibody GTX30809 at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
TDP43 antibody
GTX30809
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetTARDBP
Overview
- SupplierGeneTex
- Product NameTDP43 antibody
- Delivery Days Customer9
- Application Supplier NoteFor ELISA: Use at a dilution of 1:1,000-1:100,000. For IHC-P: Use at a dilution of 1:50-1:100. For WB: Use at a dilution of 1:100-1:1,000. Optimal dilutions/concentrations should be determined by the end user.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration667 ug/ml
- ConjugateUnconjugated
- Gene ID23435
- Target nameTARDBP
- Target descriptionTAR DNA binding protein
- Target synonymsALS10; TAR DNA-binding protein 43; TAR DNA-binding protein-43; TDP-43
- HostRabbit
- IsotypeIgG
- Protein IDQ13148
- Protein NameTAR DNA-binding protein 43
- Scientific DescriptionHIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43. Wang IF et al., 2012 Sep 11, Proc Natl Acad Sci U S ARead more
- Regulation of autophagy by neuropathological protein TDP-43. Bose JK et al., 2011 Dec 30, J Biol ChemRead more