TEAD1 Antibody

Cusabio

TEAD1 Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

TEAD1

TEA domain transcription factor 1

AA; NTEF-1; protein GT-IIC; REF1; TCF13; TCF-13; TEA domain family member 1 (SV40 transcriptional enhancer factor); TEAD-1; TEF-1; transcription factor 13; transcriptional enhancer factor 1; transcriptional enhancer factor TEF-1

Rabbit

IgG

Transcriptional enhancer factor TEF-1

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC \\\enhansons\\\ (5\\\-GTGGAATGT-3\\\) and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Human

-20°C or -80°C

12352203