TET1 antibody [GT465]

GeneTex

TET1 antibody [GT465]

9

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

GT465

1 mg/ml

Unconjugated

TET1

tet methylcytosine dioxygenase 1

bA119F7.1; CXXC finger 6; CXXC zinc finger 6; CXXC6; CXXC-type zinc finger protein 6; LCX; leukemia-associated protein with a CXXC domain; methylcytosine dioxygenase TET1; ten-eleven translocation 1 gene protein; ten-eleven translocation-1; tet oncogene 1; TET1 splice variant VP_DE4; TET1 splice variant VP_DE456

Mouse

IgG1

Methylcytosine dioxygenase TET1

Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.

-20°C or -80°C,2°C to 8°C

12352203