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ProductsBack/TET2 antibody [N2-2], N-term

TET2 antibody [N2-2], N-term

GTX124205
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetTET2
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Overview

  • Supplier
    GeneTex
  • Product Name
    TET2 antibody [N2-2], N-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.35 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID54790
  • Target name
    TET2
  • Target description
    tet methylcytosine dioxygenase 2
  • Target synonyms
    IMD75; KIAA1546; MDS; methylcytosine dioxygenase TET2; probable methylcytosine dioxygenase TET2; ten-eleven translocation 2; tet oncogene family member 2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ6N021
  • Protein Name
    Methylcytosine dioxygenase TET2
  • Scientific Description
    The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Epigenetic upregulation of TET2 is an independent poor prognostic factor for intrahepatic cholangiocarcinoma. Yamashita H et al., 2022 May, Virchows Arch
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  • Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring. Chen W et al., 2021 Nov 2, Cell Rep
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  • Epigenetic underpinnings of freeze avoidance in the goldenrod gall moth, Epiblema scudderiana. Williamson SM et al., 2021 Oct, J Insect Physiol
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  • miR-190 promotes malignant transformation and progression of human urothelial cells through CDKN1B/p27 inhibition. Huang S et al., 2021 Apr 29, Cancer Cell Int
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  • Genome-wide 5-Hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer. Wu SL et al., 2021 Feb, Genomics Proteomics Bioinformatics
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  • Autophagy restricts mitochondrial DNA damage-induced release of ENDOG (endonuclease G) to regulate genome stability. Chao T et al., 2021 Nov, Autophagy
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  • Changes in DNA 5-Hydroxymethylcytosine Levels and the Underlying Mechanism in Non-functioning Pituitary Adenomas. Xu Y et al., 2020, Front Endocrinol (Lausanne)
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  • Hydrogen sulfide attenuates renal fibrosis by inducing TET-dependent DNA demethylation on Klotho promoter. Gu Y et al., 2020 Sep, FASEB J
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  • HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML. Huang F et al., 2020 Jul 29, Aging (Albany NY)
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  • Methyl-CpG Binding Domain Protein 2 Inhibits the Malignant Characteristic of Lung Adenocarcinoma through the Epigenetic Modulation of 10 to 11 Translocation 1 and miR-200s. Pei YF et al., 2019 May, Am J Pathol
    Read more