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TGF beta antibody [TB21]

GTX76527
GeneTex
ApplicationsFlow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetTGFB1
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Overview

  • Supplier
    GeneTex
  • Product Name
    TGF beta antibody [TB21]
  • Delivery Days Customer
    9
  • Applications
    Flow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    TB21
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7040
  • Target name
    TGFB1
  • Target description
    transforming growth factor beta 1
  • Target synonyms
    CED; DPD1; IBDIMDE; LAP; latency-associated peptide; prepro-transforming growth factor beta-1; TGFB; TGFbeta; TGF-beta1; TGF-beta-1; transforming growth factor beta1; transforming growth factor beta-1 proprotein
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Topical Losartan and Corticosteroid Additively Inhibit Corneal Stromal Myofibroblast Generation and Scarring Fibrosis After Alkali Burn Injury.
    Read more
  • In Ovarian Cancer Multicellular Spheroids, Platelet Releasate Promotes Growth, Expansion of ALDH+ and CD133+ Cancer Stem Cells, and Protection against the Cytotoxic Effects of Cisplatin, Carboplatin and Paclitaxel. Casagrande N et al., 2021 Mar 16, Int J Mol Sci
    Read more
  • Heterotopic ossification in a patient with diffuse idiopathic skeletal hyperostosis: Input from histological findings. Licini C et al., 2020 Dec 3, Eur J Histochem
    Read more
  • TGFbeta1 and TGFbeta2 proteins in corneas with and without stromal fibrosis: Delayed regeneration of apical epithelial growth factor barrier and the epithelial basement membrane in corneas with stromal fibrosis. de Oliveira RC et al., 2021 Jan, Exp Eye Res
    Read more
  • Anti-CD206 antibody-conjugated Fe3O4-based PLGA nanoparticles selectively promote tumor-associated macrophages to polarize to the pro-inflammatory subtype. Zhou Y et al., 2020 Dec, Oncol Lett
    Read more
  • Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance. Li L et al., 2020 Aug 8, Breast Cancer Res
    Read more
  • The role of transforming growth factor-beta (TGF-beta1) in postmenopausal women with pelvic organ prolapse: An immunohistochemical study. Carlin GL et al., 2020 Jul, Eur J Obstet Gynecol Reprod Biol X
    Read more
  • Notch4-dependent antagonism of canonical TGF-beta1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells. Grabias BM et al., 2013 Jul 1, Am J Physiol Renal Physiol
    Read more
  • Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence-related prognostic indicator in stage I esophageal squamous cell carcinoma. Lee E et al., 2013 May 1, Cancer
    Read more
  • Analysis of molecular mechanisms and anti-tumoural effects of zoledronic acid in breast cancer cells. Insalaco L et al., 2012 Sep, J Cell Mol Med
    Read more

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