Western Blot analysis of MCF7 cells using TGFB1 Polyclonal Antibody at dilution of 1:2000.
Western Blot analysis of MCF7 cells using TGFB1 Polyclonal Antibody at dilution of 1:2000.
TGFbeta1 Polyclonal Antibody
E-AB-33090
Product group Antibodies
Overview
- SupplierElabscience
- Product NameTGFbeta1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierWB,IHC,IF,ELISA
- CertificationResearch Use Only
- Concentration1 mg/ml
- Scientific DescriptionMultifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
- UNSPSC12352203