Thymidylate synthase antibody [HMV305] HistoMAX(tm)

GeneTex

Thymidylate synthase antibody [HMV305] HistoMAX(tm)

7

IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Research Use Only

Monoclonal

HMV305

0.44 mg/ml

Unconjugated

Liquid

TYMS

thymidylate synthetase

HST422; thymidylate synthase; TMS; TS; TSase

Rabbit

IgG

Thymidylate synthase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]

-20°C or -80°C,2°C to 8°C

12352203