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Thymidylate synthase antibody [N3C3]

GTX113289
GeneTex
ApplicationsWestern Blot
Product group Antibodies
TargetTYMS
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Overview

  • Supplier
    GeneTex
  • Product Name
    Thymidylate synthase antibody [N3C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.53 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7298
  • Target name
    TYMS
  • Target description
    thymidylate synthetase
  • Target synonyms
    DKCD, HST422, TMS, TS, thymidylate synthase, TSase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP04818
  • Protein Name
    Thymidylate synthase
  • Scientific Description
    Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Hsin IL, Chou YH, Hung WL, et al. The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death. Cancers (Basel). 2019,12(1). doi: 10.3390/cancers12010108
    Read this paper
  • Ko JL, Lin CH, Chen HC, et al. Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018,33(11):1153-1159. doi: 10.1002/tox.22621
    Read this paper

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