Thymidylate synthase antibody [N3C3]
GTX113289
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Zebra Fish
TargetTYMS
Overview
- SupplierGeneTex
- Product NameThymidylate synthase antibody [N3C3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.53 mg/ml
- ConjugateUnconjugated
- Gene ID7298
- Target nameTYMS
- Target descriptionthymidylate synthetase
- Target synonymsHST422; thymidylate synthase; TMS; TS; TSase
- HostRabbit
- IsotypeIgG
- Protein IDP04818
- Protein NameThymidylate synthase
- Scientific DescriptionThymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq]
- ReactivityHuman, Zebra Fish
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death. Hsin IL et al., 2019 Dec 31, Cancers (Basel)Read more
- Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Ko JL et al., 2018 Nov, Environ ToxicolRead more