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Inhibition of TNFalpha-induced genes by TNF-R1 (human):Fc (human) (rec.) (AG-40B-0074). Methods: Endothelial cells (HUVEC) are incubated for 1h in the presence of BAY 11-7082 (AG-CR1-0013) and then treated with TNFalpha (AG-40B-0006) (20ng/ml)

TNF-R1 (human):Fc (human) (rec.)

Name: TNF-R1 (human):Fc (human) (rec.)
SKU: AG-40B-0074_A27
Availability: BackOrder

AG-40B-0074

Protein IDP19438

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Product group Proteins / Signaling Molecules

Overview

Supplier
AdipoGen Life Sciences
Product Name
TNF-R1 (human):Fc (human) (rec.)
Delivery Days Customer
10
Certification
Research Use Only
Concentration
1 mg/ml
Estimated Purity
>95%
Protein IDP19438
Protein Name
Tumor necrosis factor receptor superfamily member 1A
Scientific Description
Protein. The extracellular domain of human TNF-R1 (aa 22-211) is fused to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: 95% (SDS-PAGE). TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. - TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
12352202

TNF-R1 (human):Fc (human) (rec.)

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Overview

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