TNIK antibody
GTX13141
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetTNIK
Overview
- SupplierGeneTex
- Product NameTNIK antibody - KO/KD Validated
- Delivery Days Customer9
- Application Supplier NoteSuggested starting dilutions are as follows: WB: 1:1000-1:10000, IHC-P: 1:100-1:1000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID23043
- Target nameTNIK
- Target descriptionTRAF2 and NCK interacting kinase
- Target synonymsMRT54; TRAF2 and NCK-interacting protein kinase
- HostRabbit
- IsotypeIgG
- Protein IDQ9UKE5
- Protein NameTRAF2 and NCK-interacting protein kinase
- Scientific DescriptionGerminal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- MAP4Ks inhibition promotes retinal neuron regeneration from Mueller glia in adult mice.Read more
- CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling.Read more
- TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin. Torres-Ayuso P et al., 2021 Jun, Cancer DiscovRead more
- Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents. Deng M et al., 2020 Sep, Sci AdvRead more
- Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target. Lee RS et al., 2019 Apr, NeoplasiaRead more
- The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons. Larhammar M et al., 2017 Nov 15, J NeurosciRead more
- The essential role of TNIK gene amplification in gastric cancer growth. Yu DH et al., 2014 Feb 24, OncogenesisRead more
- Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth. Shitashige M et al., 2010 Jun 15, Cancer ResRead more