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TNIK antibody

GTX13141
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetTNIK
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Overview

  • Supplier
    GeneTex
  • Product Name
    TNIK antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    Suggested starting dilutions are as follows: WB: 1:1000-1:10000, IHC-P: 1:100-1:1000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID23043
  • Target name
    TNIK
  • Target description
    TRAF2 and NCK interacting kinase
  • Target synonyms
    MRT54, TRAF2 and NCK-interacting protein kinase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9UKE5
  • Protein Name
    TRAF2 and NCK-interacting protein kinase
  • Scientific Description
    Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Zhang H, Guo Y, Yang Y, et al. MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice. NPJ Regen Med. 2023,8(1):36. doi: 10.1038/s41536-023-00310-6
    Read this paper
  • Serwe G, Kachaner D, Gagnon J, et al. CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling. Nat Commun. 2023,14(1):3560. doi: 10.1038/s41467-023-39281-z
    Read this paper
  • Torres-Ayuso P, An E, Nyswaner KM, et al. TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin. Cancer Discov. 2021,11(6):1411-1423. doi: 10.1158/2159-8290.CD-20-0797
    Read this paper
  • Deng M, Lin J, Nowsheen S, et al. Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents. Sci Adv. 2020,6(37). doi: 10.1126/sciadv.abb2630
    Read this paper
  • Lee RS, Zhang L, Berger A, et al. Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target. Neoplasia. 2019,21(4):389-400. doi: 10.1016/j.neo.2019.02.005
    Read this paper
  • Larhammar M, Huntwork-Rodriguez S, Rudhard Y, et al. The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons. J Neurosci. 2017,37(46):11074-11084. doi: 10.1523/JNEUROSCI.0905-17.2017
    Read this paper
  • Yu DH, Zhang X, Wang H, et al. The essential role of TNIK gene amplification in gastric cancer growth. Oncogenesis. 2014,2(2):e89. doi: 10.1038/oncsis.2014.2
    Read this paper
  • Shitashige M, Satow R, Jigami T, et al. Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth. Cancer Res. 2010,70(12):5024-33. doi: 10.1158/0008-5472.CAN-10-0306
    Read this paper

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Figure 1. Western blot analysis of TNIK using anti-TNIK antibody (A03934-3). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human K562 whole cell lysates, Lane 2: human HEL whole cell lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-TNIK antigen affinity purified polyclonal antibody (Catalog # A03934-3) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for TNIK at approximately 180,150 kDa. The expected band size for TNIK is at 155 kDa.
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