tPA antibody [HL2585]

GeneTex

tPA antibody [HL2585]

9

WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

HL2585

1 mg/ml

Unconjugated

PLAT

plasminogen activator, tissue type

alteplase; plasminogen/activator kringle; reteplase; tissue-type plasminogen activator; TPA; T-PA; t-plasminogen activator

Rabbit

IgG

Tissue-type plasminogen activator

This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203