TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)

TargetMol Chemicals

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)

16

Research Use Only

DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

-20°C

12352202