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Transgelin / SM22-alpha(TAGLN/247), CF405S conjugate, 0.1mg/mL [26628-22-8]

Transgelin / SM22-alpha(TAGLN/247), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC040247
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse, Porcine, Rabbit
TargetTAGLN
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Overview

  • Supplier
    Biotium
  • Product Name
    Transgelin / SM22-alpha(TAGLN/247), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    TAGLN/247
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID6876
  • Target name
    TAGLN
  • Target description
    transgelin
  • Target synonyms
    22 kDa actin-binding protein; epididymis secretory sperm binding protein; SM22; SM22-alpha; SMCC; smooth muscle protein 22-alpha; TAGLN1; transgelin; transgelin variant 2; WS3-10
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ01995
  • Protein Name
    Transgelin
  • Scientific Description
    This MAb recognizes a 22 kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is downregulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse, Porcine, Rabbit
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203