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Transglutaminase 2 antibody [N3C3]

GTX111702
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetTGM2
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Overview

  • Supplier
    GeneTex
  • Product Name
    Transglutaminase 2 antibody [N3C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.05 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7052
  • Target name
    TGM2
  • Target description
    transglutaminase 2
  • Target synonyms
    G(h), TG(C), TGC, hTG2, tTG, protein-glutamine gamma-glutamyltransferase 2, C polypeptide, protein-glutamine-gamma-glutamyltransferase, TGase C, TGase H, TGase II, TGase-2, erythrocyte transglutaminase, heart G alpha(h), hhG alpha(h), isopeptidase TGM2, protein G alpha(h), protein-glutamine deamidase TGM2, protein-glutamine dopaminyltransferase TGM2, protein-glutamine histaminyltransferase TGM2, protein-glutamine noradrenalinyltransferase TGM2, protein-glutamine serotonyltransferase TGM2, tTgase, tissue transglutaminase, transglutaminase C, transglutaminase H, transglutaminase II
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP21980
  • Protein Name
    Protein-glutamine gamma-glutamyltransferase 2
  • Scientific Description
    Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Cao Q, Tartaglia G, Alexander M, et al. Collagen VII maintains proteostasis in dermal fibroblasts by scaffolding TANGO1 cargo. Matrix Biol. 2022,111:226-244. doi: 10.1016/j.matbio.2022.06.008
    Read this paper
  • Xu P, Chen C, Zhang Y, et al. Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis. Cell Metab. 2022,34(2):299-316.e6. doi: 10.1016/j.cmet.2021.12.019
    Read this paper
  • Morotomi-Yano K, Yano KI. Calcium-dependent activation of transglutaminase 2 by nanosecond pulsed electric fields. FEBS Open Bio. 2017,7(7):934-943. doi: 10.1002/2211-5463.12227
    Read this paper
  • Yeo SY, Itahana Y, Guo AK, et al. Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. Elife. 2016,5:e07101. doi: 10.7554/eLife.07101
    Read this paper
  • Costa-Almeida R, Gomez-Lazaro M, Ramalho C, et al. Fibroblast-endothelial partners for vascularization strategies in tissue engineering. Tissue Eng Part A. 2015,21(5-6):1055-65. doi: 10.1089/ten.TEA.2014.0443
    Read this paper