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Transglutaminase 2 antibody [N3C3]

Research Use Only
GTX111702
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetTGM2
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Overview

  • Supplier
    GeneTex
  • Product Name
    Transglutaminase 2 antibody [N3C3]
  • Delivery Days Customer
    9
  • Antibody Specificity
    Knockdown/Knockout validation was supported by references (PMID:26956429).
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.05 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID7052
  • Target name
    TGM2
  • Target description
    transglutaminase 2
  • Target synonyms
    C polypeptide, protein-glutamine-gamma-glutamyltransferase; erythrocyte transglutaminase; G(h); heart G alpha(h); hhG alpha(h); hTG2; isopeptidase TGM2; protein G alpha(h); protein-glutamine deamidase TGM2; protein-glutamine dopaminyltransferase TGM2; protein-glutamine gamma-glutamyltransferase 2; protein-glutamine histaminyltransferase TGM2; protein-glutamine noradrenalinyltransferase TGM2; protein-glutamine serotonyltransferase TGM2; TG(C); TGase C; TGase H; TGase II; TGase-2; TGC; tissue transglutaminase; transglutaminase C; transglutaminase H; transglutaminase II; tTG; tTgase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP21980
  • Protein Name
    Protein-glutamine gamma-glutamyltransferase 2
  • Scientific Description
    Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis. Xu P et al., 2022 Feb 1, Cell Metab
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  • Calcium-dependent activation of transglutaminase 2 by nanosecond pulsed electric fields. Morotomi-Yano K et al., 2017 Jul, FEBS Open Bio
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  • Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. Yeo SY et al., 2016 Mar 9, Elife
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  • Fibroblast-endothelial partners for vascularization strategies in tissue engineering. Costa-Almeida R et al., 2015 Mar, Tissue Eng Part A
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